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Description: ABT-737 is a novel, potent, selective and orally available BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in enzymatic assays, respectively. It does not inhibit Mcl-1, Bcl-B or Bfl-1 etc. It is currently in Phase 2 clinical trial for cancer treatment.

1.1 Produktbeteckningar. Produktnamn. : Bcl-2 Inhibitor VI, ABT-737. PRb / E2F-1-medierad kaspasberoende induktion av Noxa förstärker de apoptotiska effekterna av Bcl-2 / Bcl-xL-hämmaren ABT-737. Effektiv inriktning på STAT5-medierad överlevnad i myeloproliferativa neoplasmer med användning av ABT-737 kombinerat med rapamycin. Cell Death & Disease 25 juli 2013. BT-263 and its structural analogues ABT-199 and ABT-737 inhibit B-cell lymphoma 2 (Bcl- funderat på, tex genom att hindra ut olika anti-apoptos proteiner (s.k BCL2 familjen) med "BH3" mimetiska molekyler (ABT-737, ABT-263).

Abt 737

2013-04-09. 36,66. 31,00. 37,76. 12,80.

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Curcumin Impurity Molecule Acromegaly ABT-737, Phenyl Azide, abt, akromegali png. Curcumin Impurity Molecule Acromegaly ABT-737, Phenyl Azide, abt,

2019-04-12. KS2019:1469. Fakturaunderlag ABT-avtal.

ABT-737 inhibits many SCLC cell lines including NCI-H889, NCI-H1963, NCI-H1417, NCI-H146 and etc. Bcl-2 and Noxa may contribute mechanistically to the cellular response to ABT-737 in NCI-H146 cells. A recent study shows that ABT-737 significantly induces apoptosis in HTLV-1 infected T-cell lines as well as in fresh AT MedChem Express HY-50907

ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells. Kline et al. Leukemia, 2007;21:1549 Product Datasheets ABT-737 disturbs the binding of B cell lymphoma (Bcl)-2 homologous antagonist killer and Bcl-extra large. ABT-737 induces a BAX/BAK-dependent impairment of maximal O 2 consumption rate in sensitive cells. Stable BCL-2 overexpression in MCF10A cells induces an ABT-737-sensitive primed for death state. ABT-737(852808-04-9) Reference standards for Pharmacological research.

Handledare: Kjell Grankvist, institutionen för 2010 (Svenska)Självständigt arbete på grundnivå (yrkesexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)Alternativ titel.
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Bcl-2 family We found that ABT-737 can induce the Bax-dependent release of apoptotic proteins (cytochrome c, Smac/Diablo and Omi/HtrA2 but not AIF) from various but not Download scientific diagram | Structure of the Bcl-xL:ABT-737 complex (right) showing the binding pockets (p2 and p4) for the chloro-biphenyl and thiophenyl 2019年10月5日賽車手因為有異於常人的駕駛技巧及對汽車性能的敏感度，因此經常會被車廠向中擔綱試車手，並且會以他的回饋作為車輛操控、性能設定的依據 A-737-1-D U型把手. 詢價下載3D Step 下載3D Step 下載3D Step. 型號: A-737-1- D. 材質：圓管-鋁合金，支座：尼龍加玻璃纖維、黑色，表面處理：鍍霧銀.

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Kline et al (2007) ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells. Leukemia 21 1549 PMID: 17460700 If you know of a relevant reference for ABT 737, please let us know.

Bak/Bax if Mcl-1 is neutralized. Cancer Cell. 2006;10(5):389-99.

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2006-11-01 · Because ABT-737 targets only certain prosurvival proteins (Bcl-2, Bcl-x L, Bcl-w), its efficacy as a single agent is restricted to tumors where prosurvival Mcl-1 is low. We show that resistant cells can be sensitized to ABT-737 by approaches that downregulate, destabilize, or inactivate Mcl-1.

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